Winter and especially the holidays are the time when heart attacks and other cardiovascular problems spike, doctors say. More cardiac deaths happen on Dec. 25, Dec. 26 and Jan. 1 than on any other days of the year, research has shown. Heart disease, which includes heart attacks, is the leading cause of death in the U.S. year-round.
Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Sildenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure (see section 5.1). Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity. Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction (e.g., aortic stenosis, hypertrophic obstructive cardiomyopathy), or those with the rare syndrome of multiple system atrophy manifesting as severely impaired autonomic control of blood pressure.
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Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development.
Dr. Amber R. Watson is a pharmacist with specialized training in drug information, medical communication, and clinical data analysis. She is currently the assistant medical director for Nashville Biosciences, a wholly owned subsidiary of Vanderbilt University Medical Center in Nashville, Tennessee. 2ff7e9595c
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